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Thank you!
We'd like to thank everyone who has contributed and continues to contribute to this project, and would like to remind everyone that there may be periods of down time while we are preparing for future large scale batches of jobs and analyzing results. We greatly appreciate your contributions which are vitally important to our ongoing research.
Thank you!
5 Nov 2020, 20:16:29 UTC · Discuss

Coronavirus update from David Baker. Thank you all for your contributions!
Here is a short video of David Baker describing some exciting results from de novo designs targeting SARS-Cov-2.
Thank you all for your contributions to this research! Although R@h was not directly used for the work described in the publication (link provided below), R@h was used for designing relevant scaffolds. Additionally, there are currently many similar designs that bind SARS-Cov-2 and related targets that were engineered using R@h.
https://www.youtube.com/embed/ODEIN5V3yLg
More information is available from the publication, De novo design of picomolar SARS-CoV-2 mini protein inhibitors.
21 Sep 2020, 23:16:33 UTC · Discuss

Switch to using SSL (Secure Socket Layer)
We updated our project to use SSL. The project URL has thus been changed to https://boinc.bakerlab.org/rosetta. You can reattach the project using this updated URL at your convenience. Please post any issues regarding this update in the discussion thread.
1 May 2020, 21:25:30 UTC · Discuss

At Rosetta Hardscapes we recognize that improving your yard is about imagining how the space will transform your lifestyle. We believe in creating more quality time in life with the ones you love. See How Rosetta Changes Your View Landscape contractor or designer? Jan 15, 2021 Rosetta 2 enables a Mac with Apple silicon to use apps built for a Mac with an Intel processor. If you have a Mac with Apple silicon, you might be asked to install Rosetta in order to open an app. Click Install, then enter your user name and password to allow installation to proceed.

Help in the fight against COVID-19!
With the recent COVID-19 outbreak, R@h has been used to predict the structure of proteins important to the disease as well as to produce new, stable mini-proteins to be used as potential therapeutics and diagnostics, like the one displayed above which is bound to part of the SARS-CoV-2 spike protein.
To help our research, we are happy to announce a new application update, and thanks to the help from the Arm development community, including Rex St. John, Dmitry Moskalchuk, David Tischler, Lloyd Watts, and Sahaj Sarup, we are excited to also include the Linux-ARM platform. With this update we will continue to make protein binders to SARS-CoV-2 and related targets using the latest Rosetta source.
Thank you R@h volunteers for your continued support to this project. Your CPU hours are used not only to accurately model the structures of important proteins, but to design new ones as well. Let's band together and fight COVID-19!
More details will be available in the Discussion of this news post.
3 Apr 2020, 3:45:24 UTC · Discuss

Designing shape-shifting proteins
Thank you to all R@h participants who provided much of the computing used in a recent study published in PNAS describing the design of proteins that adopt more than one well-folded structure, reminiscent of viral fusion proteins.
For more infomation, click here.
19 Mar 2020, 0:47:01 UTC · Discuss

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Rosetta™ is a molecular modeling software package for understanding protein structures, protein design, protein docking, protein-DNA and protein-protein interactions. The Rosetta software contains multiple functional modules, including RosettaAbinitio, RosettaDesign, RosettaDock, RosettaAntibody, RosettaFragments, RosettaNMR, RosettaDNA, RosettaRNA, RosettaLigand, RosettaSymmetry, and more. For a list of current features, see current release notes.

PyRosetta can be found here.

Rosetta Lenoire

For more information: http://www.rosettacommons.org/

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Rosetta Mac

To license this product please contact UW CoMotion at license@uw.edu

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